This
note covers the following topics: Basic Quantum Mechanics, UV absorption,
Fluorescence, Circular Dichroism, IR/Raman, Intro Proteins, NMR, Solid State NMR,
Single molecule, Protein-DNA Interactions, Calorimitry, X-ray, Electron
Microscopy, Mass Spectrometry.
Author(s): University of Pittsburgh School of Medicine
This note covers the
following topics: Structural Biology and Amino acids, History of Macromolecular Crystallography, Amino acid Chirality,
Non-covalent interactions and Ramachandran Map, Secondary structures;
Introduction to Protein , Alpha-domain proteins I: Coiled coils and four-helix
bundle, ROP protein design, Alpha-domain proteins II: Large alpha-helical domain
and globin fold, Alpha or Beta-domain proteins, Beta-domain proteins.
This note aims
to provide the knowledge of the basic protein molecular architecture and then to
connect it to the basic cellular processes like enzymatic activity, transport
and membrane functions.
This note explains the following topics: Taxonomy : Primary and Secondary
Structure, Motifs and Supersecondary Structure, Tertiary Structure and Fold
Types, Forces that Determine Protein Structure, Mechanisms of Protein Folding,
Multiscale Modeling of Electrostatics.