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Bio Organic Chemistry of Natural Enediyne Anticancer Antibiotics

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Bio Organic Chemistry of Natural Enediyne Anticancer Antibiotics

Bio Organic Chemistry of Natural Enediyne Anticancer Antibiotics

In this note the basics of enediyne class of natural and designed antitumor antibiotics, their history of discovery, novel biological activity, and their medicinal application will be focused. Also this note will describe the history of discovery of enediyne class of natural products, their molecular architechture, mode of biological action and the key chemistry behind their potent DNA cleaving activity.

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