Twelve articles reproduced from the following Annual Reviews Series:

Annual Review of Biophysics and Biomolecular Structure, Annual Review of Cell and Developmental Biology, Annual Review of Biochemistry, Annual Review of Genomics and Human Genetics, and Annual Review of Microbiology.

Contents

• Minor Groove-Binding Architectural Proteins: Structure, Function, and DNA Recognition
  Carole A Bewley, Angela M Gronenborn, and G. Marius Clore.
  • Introduction
  • Structure and Function of Minor Groove-Binding Architectural Factors
  • Factors Contributing to Specific Binding and Conformational Changes
  • Conclusions
  • Acknowledgments
  • Literature Cited
• Ubiquitin and the Control of Protein Fate in the Secretory and Endocytic Pathways
  Juan S Bonifacino and Allan M Weissman.
  • Introduction
  • Overview of the Ubiquitin-Proteasome Degradation System
  • Degradation of ER-Retained Proteins by the Ubiquitin-Proteasome System
  • Ubiquitination of Plasma Membrane Proteins
  • Perspectives
  • Acknowledgments
  • Literature Cited
• Role of Small G Proteins in Yeast Cell Polarization and Wall Biosynthesis
  Enrico Cabib, Jana Drgonová, and Tomás Drgon.
  • Introduction
  • Where to Start
  • Preparing to Grow
  • Building New Cell Wall
  • Small G Proteins Musings
  • Acknowledgments
  • Literature Cited
• GCN5-Related N-Acetyltransferases: A Structural Overview
  Fred Dyda, David C Klein, and Alison B Hickman.
  • Introduction
  • Description of the Structure
  • Substrate Binding
  • Chemical Catalysis
  • Summary
  • Literature Cited
• Fast Kinetics and Mechanisms in Protein Folding
  William A Eaton, Victor Muñoz, Stephen J Hagen, Gouri S Jas, Lisa J Lapidus, Eric R Henry, and James Hofrichter.
  • Introduction and Overview
  • Basic Ideas of Fast-Folding Methods
  • Elementary Processes in Folding
  • Fast Protein Folding
  • Protein-Folding Rates from a Simple Model
  • Biological Relevance of Folding Kinetics
  • Literature Cited
• Dynamin and its Role in Membrane Fission
  J. E Hinshaw.
  • Introduction
  • Dynamin Domains
  • Regulation of Dynamin Self-Assembly
  • Dynamin Phosphorylation and Calcium Binding
  • Dynamin and Membrane Recycling
  • Dynamin Partners
  • Dynamin-Like Proteins
  • Summary
  • Acknowledgments
  • Literature Cited
• Signaling and Subcellular Targeting by Membrane-Binding Domains
  James H Hurley and Saurav Misra.
  • Perspectives and Overview
  • C1 Domains
  • C2 Domains
  • FYVE Domains
  • Pleckstrin Homology Domains
  • Other Membrane-Binding Domains
  • Concluding Remarks
  • Acknowledgments
  • Literature Cited
• Secretory Protein Trafficking and Organelle Dynamics in Living Cells
  Jennifer Lippincott-Schwartz, Theresa H Roberts, and Koret Hirschberg.
  • Introduction
  • ER Organization, Continuity, and Retention
  • ER-to-Golgi Transport
  • Dynamics of the Golgi Complex
  • Golgi to Plasma Membrane Transport
  • Kinetic Analysis of Secretory Transport
  • Summary and Perspectives
  • Acknowledgments
  • Literature Cited
• Regulation of Phosphoinositide-Specific Phospholipase C
  Sue Goo Rhee.
  • Introduction
  • Structural Organization of PLC Isozymes
  • Structure and Reaction Mechanism of PLC
  • Activation of PLC-β Isozymes by Heterotrimeric G Proteins
  • Activation of PLC-γ Isozymes
  • Activation of PLC-δ Isozymes
  • Activation of PLC-ε
  • Concluding Remarks
  • Acknowledgment
  • Literature Cited
• Mechanisms of Viral Interference with MHC Class I Antigen Processing and Presentation
  Jonathan W Yewdell and Jack R Bennink.
  • Introduction
  • Viral Interference with Antigen Processing
  • Future Challenges
  • Literature Cited
• How Many Genes Can Make a Cell: The Minimal-Gene-Set Concept
  Eugene V. Koonin.
  • Background and History of the Minimal-Gene-Set Concept
  • The Current Status of the Minimal Gene Set
  • Nonorthologous Gene Displacement—A Minimal Gene Set or a Minimal Set of Functions?
  • Extension and Development of the Minimal-Gene-Set Concept
  • Conclusions
  • Acknowledgments
  • Literature Cited
• Horizontal Gene Transfer in Prokaryotes: Quantification and Classification
  Eugene V. Koonin, Kira S. Makarova, and L. Aravind.
  • Introduction
  • Criteria for Detecting Horizontally Transferred Genes
  • Classification and Quantification of Horizontal Gene Transfer Events
  • Horizontal Gene Transfer from Eukaryotes to Bacteria and Archaea
  • Conclusions
  • Acknowledgments
  • Literature Cited