major focus of the note is understanding mass spectra, so the majority of the
problem sets will involve interpretation of mass spectra of unknowns. Topics
covered includes: Interpretation of Electron Impact, Ion sources, Mass
Analyzers, MS/MS and fragmentation methods, Mass Spectrometry in the Real World,
Protein complexes and ydrogen and Deuterium Exchange, Imaging Mass Spectrometry,
2D FTICR mass spectrometry.
This course note
will develop Mass Spectrometry as an analytical tool in chemistry and
biochemistry, at an advanced level. Topics covered includes ionization, mass
analyzers, ion dissociation, ion mobility, qualitative and quantitative analysis
with various applications.