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Mass Spectrometry Basics for Young Students An Interactive Laboratory Tour
This guide is designed to introduce young students aged between 6 and 14 to the field of mass spectrometry in a highly interactive and hands-on laboratory experience. It describes the basic principles of the technique in a way that is fun and accessible for children. It can be adapted in modules to accomodate various age groups, providing an educational approach to an introduction to the field of mass spectrometry. This resource sparks young minds toward exploration of scientific concepts, especially in chemistry and biology, and encourages curiosity about the world of molecular analysis.
Author(s): American Society for Mass Spectrometry
36 Pages 
This resource from the Scripps Center for Metabolomics introduces the fundamental concepts of mass spectrometry (MS), so it is very good for beginners. It includes the most essential facts about MS that concern the principles of ionization, mass analyzers, and detectors, as well as information on the vacuum system required for MS analysis. The note gives foundational knowledge of how MS works: from the generation of ions from a sample to the separation process and on to detection. Suitable for practitioners who are just beginning a career in analytical chemistry or metabolomics, it provides an easily accessible introduction to the technology and applications in the analysis of complex molecular systems.
Author(s): Scripps Center for Metabolomics
NA Pages
This advanced PDF explores mass spectrometry from the computational and algorithmic perspective. Peptide de novo sequencing, database searching, and comparing mass spectra using significance testing, such as p-values and E-values, are discussed in this note. It also covers isotope distributions and fragmentation patterns to shed light on the mathematical aspects behind its analysis of mass spectrometry data. It reaches more complex dimensions and discusses issues like glycan sequencing, machine learning, and decomposition of the isotope pattern. Finally, the note is an invaluable resource for anyone interested in mass spectrometry and computational methods, providing a foundation for yet more complicated applications in bioinformatics and structural biology.
Author(s): Sebastian Bocker
253 Pages