Prof.
Peter B. O'Connor's note on mass spectrometry. It deals with the interpretation
of mass spectra; it would be particularly useful for any persons undertaking the
analysis of unknown samples. It starts by dealing with a range of techniques,
among them being electron impact ionization, MS/MS fragmentation, and ion
sources. In addition, the note goes into practical implementations of mass
spectrometry in real-world applications such as protein complex analysis,
hydrogen and deuterium exchange, and imaging mass spectrometry. The course takes
the student through advanced topics like 2D FTICR mass spectrometry, an
expansive full view of modern mass spectrometric methods and their practical use
in research and industry.
This resource from the Scripps Center for Metabolomics
introduces the fundamental concepts of mass spectrometry (MS), so it is very
good for beginners. It includes the most essential facts about MS that concern
the principles of ionization, mass analyzers, and detectors, as well as
information on the vacuum system required for MS analysis. The note gives
foundational knowledge of how MS works: from the generation of ions from a
sample to the separation process and on to detection. Suitable for practitioners
who are just beginning a career in analytical chemistry or metabolomics, it
provides an easily accessible introduction to the technology and applications in
the analysis of complex molecular systems.
Prof.
Peter B. O'Connor's note on mass spectrometry. It deals with the interpretation
of mass spectra; it would be particularly useful for any persons undertaking the
analysis of unknown samples. It starts by dealing with a range of techniques,
among them being electron impact ionization, MS/MS fragmentation, and ion
sources. In addition, the note goes into practical implementations of mass
spectrometry in real-world applications such as protein complex analysis,
hydrogen and deuterium exchange, and imaging mass spectrometry. The course takes
the student through advanced topics like 2D FTICR mass spectrometry, an
expansive full view of modern mass spectrometric methods and their practical use
in research and industry.