This note covers the following
topics: Structure of DNA, Base-pair Interactions and DNA Melting, Mechanics
and Statistical Mechanics of DNA, Electrostatics of DNA and DNA -DNA
Interactions, DNA Collapse and DNA Mesophases, DNA Organization in Chromatin
This introductory note on biophysics
introduces the principles of electrical excitability of cell membranes, which
form the basis of all information processing in the nervous system. Topics
covered includes: neurons and the brain, Electrical properties of cells,
Hodgkin-Huxley model of action potentials, Synapses and Perceptrons.
The topics that will be
presented this note include an introduction to the elementary
structure of DNA, proteins, membranes, and cells, and the physical principles
that govern the resulting structures.
The topics that will be presented in
this course note include an introduction to the elementary structure of DNA,
proteins, membranes, and cells, and the physical principles that govern the
resulting structures. Here, the physical quantities such as temperature, energy,
enthalpy, entropy, and free energy will be employed to understand why a
biological system chooses particular state at conditions under study.
This note covers
the following topics: Minimal Biosystems, Optimal BioSystems, DNA: Genotyping
and Biome sequencing, RNA: Quantitation concepts and Clustering by gene or
condition and other regulon data sources, Protein: 3D structural genomics,
homology, catalytic and regulatory dynamics, function and drug design, Mass
spectrometry, post-synthetic modifications, quantitation of proteins,
metabolites and interactions.
This note covers the
following topics: Michaelis-Menten kinetics, equilibrium binding, Lambda
phage, multistability, synthetic genetic switches, stability analysis,
introduction to E.coli chemotaxis, Fine-tuned versus Robust chemotaxis models,
wrapping up chemotaxis, genetic oscillators, stochastic chemical
kinetics, cell systems biology-'the importance of diffusion and gradients for
cellular regulation', Quorum sensing, Drosophila development.
This course provides a survey of problems
at the interface of statistical physics and modern biology. Topics covered
includes: bioinformatic methods for extracting information content of DNA,
gene finding, sequence comparison, and phylogenetic trees, physical
interactions responsible for structure of biopolymers, DNA double helix,
secondary structure of RNA, and elements of protein folding, considerations of
force, motion, and packaging, protein motors and membranes.
Mehran Kardar and Prof. Leonid Mirny