Antivirals Virology
The contents
of this lecture presentation include : Vaccines can prevent viral disease, Why
are there so few antiviral drugs?, Antiviral history, Blind screening, Antiviral
discovery today, The path of drug discovery, Mechanism-based screens, Cell-based
screen, Antiviral screening, High throughput screening, Dangers of drug
resistance, Mechanisms of drug resistance, Acyclovir mechanism of action,
Improving acyclovir, Acyclovir-resistant HSV, Symmetrel, Influenza virus NA
inhibitors, WIN compounds, Inhibitors of picornavirus uncoating, New HCV drugs,
HCV new drug pipeline, Azido-deoxythymidine, AZT, Non-nucleoside RT inhibitors,
IN inhibitors, Maraviroc: CCR5 inhibitor, Combination therapy, Mathematics of
drug resistance, ART saves lives, Pre-exposure prophylaxis.
Author(s): Prof. Vincent Racaniello, Columbia University
61 Pages