This
note covers the following topics: Basic Quantum Mechanics, UV absorption,
Fluorescence, Circular Dichroism, IR/Raman, Intro Proteins, NMR, Solid State NMR,
Single molecule, Protein-DNA Interactions, Calorimitry, X-ray, Electron
Microscopy, Mass Spectrometry.
Author(s): University of Pittsburgh School of Medicine
This
note covers the following topics: Basic Quantum Mechanics, UV absorption,
Fluorescence, Circular Dichroism, IR/Raman, Intro Proteins, NMR, Solid State NMR,
Single molecule, Protein-DNA Interactions, Calorimitry, X-ray, Electron
Microscopy, Mass Spectrometry.
Author(s): University of Pittsburgh School of Medicine
This note covers the
following topics: Structural Biology and Amino acids, History of Macromolecular Crystallography, Amino acid Chirality,
Non-covalent interactions and Ramachandran Map, Secondary structures;
Introduction to Protein , Alpha-domain proteins I: Coiled coils and four-helix
bundle, ROP protein design, Alpha-domain proteins II: Large alpha-helical domain
and globin fold, Alpha or Beta-domain proteins, Beta-domain proteins.
This note explores the
concepts and algorithms that enable computational modeling of biological
molecules, in both theory and practice. Topics covered includes: The basics of
protein structure, Rosetta and structural modeling, Optimization techniques,
Analysis of protein structures and assessment of model quality, Full atom
refinement and side chain modeling, Hands-on: Side chain modeling, Homology
modelin, Protein-protein docking.
The aim of this book is that a non expert
can gain some appreciation for the intricacies involved, and in the current
state of affairs. The expert meanwhile, can gain a deeper understanding of the
topic.
This note explains the following topics: Taxonomy : Primary and Secondary
Structure, Motifs and Supersecondary Structure, Tertiary Structure and Fold
Types, Forces that Determine Protein Structure, Mechanisms of Protein Folding,
Multiscale Modeling of Electrostatics.